Bispecific transduction enhancers

Compositions and methods for transducing immune cells in vivo are provided in which a multispecific antibody (e.g., a bispecific T-cell adapter) is administered to make immune cells in a subject more readily transduced by a vector, such as a lentiviral vector. 提供了用于体内转导免疫细胞的组合物和方法，其中施用多特异性抗体(例如双特异性T...

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Bibliographische Detailangaben
Hauptverfasser:	CHRISMAN RAY, NICOLAS, C, B.RYOU, GREEN SHALOM, SCHALLENBERG ALEXANDER, BATES LORRAINE, MICHEL KRISTIN, DRIC, SULLIVAN ADAM
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Compositions and methods for transducing immune cells in vivo are provided in which a multispecific antibody (e.g., a bispecific T-cell adapter) is administered to make immune cells in a subject more readily transduced by a vector, such as a lentiviral vector. 提供了用于体内转导免疫细胞的组合物和方法，其中施用多特异性抗体(例如双特异性T细胞衔接器)以使受试者中的免疫细胞更易被载体如慢病毒载体转导。