Immunomodulatory compositions and uses thereof

Chimeric molecules comprising a fibrinogen-related domain (FRED) from human fibrinogen-like protein 2 (FGL2) are provided. Also provided are immunomodulatory pharmaceutical compositions comprising the chimeric molecules, and methods of reducing inflammation and treating autoimmune diseases in a subject by administering the chimeric molecules or immunomodulatory pharmaceutical compositions. 提供了包含来自人纤维蛋白原样蛋白2(FGL2)的纤维蛋白原相关结构域(FRED)的嵌合分子。还提供了包含所述嵌合分子的免疫调节药物组合物，以及通过施用所述嵌合分子或免疫调节药物组合物来减轻受试者的炎症和治疗自身免疫性疾病的方法。