Silk protein microneedle and preparation method thereof

The preparation method of the silk protein microneedle comprises the following steps: preparing a silk protein solution; preparing the silk protein drug-loaded microspheres; preparing a fibroin drug-loaded microsphere master batch and a fibroin master batch through spray drying; adding the fibroin drug-loaded microsphere master batch into deionized water, and mechanically stirring and whipping to obtain fibroin drug-loaded microsphere paste; a microneedle array mold is obtained through 3D printing of a resin material; the preparation method comprises the following steps: coating a mold with fibroin drug-loaded microsphere paste, drying for a period of time, laying fibroin master batches and a flexible material in the mold in a layered manner, and pressing and forming to obtain the functional fibroin microneedle with a porous structure. The microneedle disclosed by the invention can realize a slow release effect of a drug, and can accurately target an action site after the surface of the microsphere is modifie