Recombinant ACE2-FC fusion molecules and methods of making and using same

A fusion protein comprising a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to an Fc domain. The variant ACE2 domain comprises an N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wild-type ACE2 having SEQ ID NO. 1. The variant ACE2 domain has AC...

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Bibliographische Detailangaben
Hauptverfasser:	LUNDY STEVEN K, ZHUO SHI, ZHU HAI, WAITE ANDREW, GILCHRIST, MARK, TSAI TSUNG-YI, ZHANG YONG, KHALILI JAHAN, MAK NGA SZE, ZHU YI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A fusion protein comprising a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to an Fc domain. The variant ACE2 domain comprises an N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wild-type ACE2 having SEQ ID NO. 1. The variant ACE2 domain has ACE2 activity. 一种融合蛋白，其包含与Fc结构域共价融合的变体血管紧张素转化酶2(ACE2)结构域。变体ACE2结构域相对于具有SEQ ID NO.1的全长野生型ACE2包含N-端缺失、C-端缺失或两者。变体ACE2结构域具有ACE2活性。