Purification method of CA16 virus inactivation liquid and preparation method of CA16 virus inactivation stock solution

The invention provides a purification method of a CA16 virus inactivation solution and a preparation method of a CA16 virus inactivation stock solution, and belongs to the technical field of biological medicines. The purification method of the CA16 virus inactivation solution provided by the inventi...

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Hauptverfasser: LU XIAOWEI, GE XIAOWEN, MAO ZHENGRUI, JIANG LI, ZHANG HAORAN, TIAN HUAPING, YANG ERXIA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a purification method of a CA16 virus inactivation solution and a preparation method of a CA16 virus inactivation stock solution, and belongs to the technical field of biological medicines. The purification method of the CA16 virus inactivation solution provided by the invention comprises the following steps: purifying the CA16 virus inactivation solution by adopting a cation exchange chromatography column to obtain a CA16 virus inactivation stock solution. The CA16 virus inactivation liquid is purified based on the cation exchange method, the concentration effect on the antigen in the virus inactivation liquid is achieved, meanwhile, impurities which cannot be removed through ultrafiltration purification can be removed, particularly, the protein content can be remarkably reduced, the purity of the effective antigen is improved, and therefore the quality of the CA16 virus inactivation liquid product is improved. 本发明提供了CA16病毒灭活液的纯化方法及CA16病毒灭活原液的制备方法,属于生物医药技术领域。本发明提供的CA16病毒灭活液的纯化方法,包括以下步骤