1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase IV inhibitory activity

具有式(I)的1-环烷基-1，8-二氮杂萘-4-酮衍生物：∴其中R#+[1]表示取代或未取代环烷基或取代或未取代杂环烷基，R#+[2]，R#+[3]，和R#+[4]独立地表示氢原子，取代或未取代低级烷基，或卤素原子，X表示基团NR#+[5]R#+[6]或基团OR#+[7]，其中R#+[5]和R#+[6]独立地表示氢原子，取代或未取代低级烷基，取代或未取代环烷基，取代或未取代芳基，或取代或未取代杂芳基，和R#+[7]表示氢原子，取代或未取代低级烷基，或取代或未取代环烷基，或其药物学上可接受的盐或其溶剂化物，以及含有它们作为有效组分的IV型磷酸二酯酶抑制剂。 A 1-cycloalkyl-1,8-naphthylidin-4-one derivative having the formula (I): wherein R indicates a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocycloalkyl group, R , R , and R independently indicate a hydrogen atom, a substituted or unsubstituted lower alkyl group, or a halogen atom, X indicates a group NR R or a group OR , wherein R and R independently indicate a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group, and R indicates a hydrogen atom, a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted cycloalkyl group or a pharmaceutically acceptable salt or solvate thereof and a type IV phosphodiesterase inhibitor containing the same as an effective component.