Medical tissue sealant composition, sealant as well as preparation method and application of sealant

The invention belongs to the technical field of medical adhesives and medical instruments, and particularly relates to a medical tissue sealant composition, a sealant and a preparation method and application of the sealant. The medical tissue sealant composition comprises a first component and a second component, wherein the first component is a polymer containing at least one active group of acid anhydride, aldehyde group, succinimide group and maleimide group; the second component is a polymer containing at least one active group of sulfydryl, amino, methylenimine, sulfenyl salt and amino salt; and the molar ratio of the active group of the first component to the active group of the second component is 1: 10-20: 1. The medical tissue sealant composition is directly subjected to a cross-linking reaction in a neutral solution to generate a hydrogel sealant, a catalyst or a cross-linking agent and the like are not needed, the gel forming time is short, for example, the gel forming time of a wound surface does