1H-pyrazolo [4, 3-d] pyrimidine compounds as Toll-like receptor 7 (TLR7) agonists

1H-pyrazolo [4, 3-d] pyrimidine compounds as Toll-like receptor 7 (TLR7) agonists

Compounds according to Formula I are useful as agonists of Toll-like Receptor 7 (TLR7). Such compounds can be used in the treatment of cancer, in particular in combination with anti-cancer immunotherapeutic agents, or as vaccine adjuvants. 根据式I的化合物可用作Toll样受体7(TLR7)的激动剂。此类化合物能够用于癌症治疗，尤其是与抗癌免疫治疗剂组合，或者...

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Hauptverfasser: CONG QIANG, TUBBY CHRISTINE M, PUDDER, YOGESH, B, HE LIQI, GANGWAR SANJEEV, GAVAI ASHVINIKUMAR V, BRUEKMA MARIANNE, O 'MALLEY DANIEL, COX MICHAEL
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds according to Formula I are useful as agonists of Toll-like Receptor 7 (TLR7). Such compounds can be used in the treatment of cancer, in particular in combination with anti-cancer immunotherapeutic agents, or as vaccine adjuvants. 根据式I的化合物可用作Toll样受体7(TLR7)的激动剂。此类化合物能够用于癌症治疗，尤其是与抗癌免疫治疗剂组合，或者用作疫苗佐剂。