Recombinant chimeric membrane protein based on Luciferase reporter gene system and application of recombinant chimeric membrane protein

The invention relates to a recombinant chimeric membrane protein based on a Luciferase reporter gene system and application of the recombinant chimeric membrane protein, the recombinant chimeric membrane protein can be used for screening specific molecular drugs aiming at CD47 or SIRP alpha and dete...

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Bibliographische Detailangaben
Hauptverfasser:	LI SHENGFENG, ZHONG YUTING, HUANG XIANMING, LIU XIANQIN, CHEN LINGJIA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a recombinant chimeric membrane protein based on a Luciferase reporter gene system and application of the recombinant chimeric membrane protein, the recombinant chimeric membrane protein can be used for screening specific molecular drugs aiming at CD47 or SIRP alpha and detecting the activity of the specific molecular drugs for blocking a CD47-SIRP alpha signal channel, and the recombinant chimeric membrane protein has the characteristics of convenience and rapidness in detection, good stability, high target specificity and the like. 本发明涉及一种基于Luciferase报告基因系统的重组嵌合膜蛋白及其应用，该重组嵌合膜蛋白可用于筛选针对CD47或SIRPα的特异性分子药物，检测其阻断CD47-SIRPα信号通路的活性，具有检测方便、快速，稳定性好，靶点特异性高等特点。