Fused pyrimidinedione compound, application thereof and pharmaceutical composition

Fused pyrimidinedione compound, application thereof and pharmaceutical composition

The invention provides a fused pyrimidinedione compound and a pharmaceutically acceptable salt thereof, the structural formula of the compound is shown in formula (I), and the compound and the pharmaceutically acceptable salt thereof can be used as a TRPC4/5 inhibitor and used for preparing a medici...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG YUJING, CAO ZHENGYU, LIU MENGRU, ZHANG ZHUANG, CUI MENGYI, WANG KAI, SHEN JIANHUA, XU TIFEI, SONG ZHAOXIANG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides a fused pyrimidinedione compound and a pharmaceutically acceptable salt thereof, the structural formula of the compound is shown in formula (I), and the compound and the pharmaceutically acceptable salt thereof can be used as a TRPC4/5 inhibitor and used for preparing a medicine for treating skin diseases related to keratinocyte lesion. 本发明提供一种稠合嘧啶二酮类化合物及其药学上可接受的盐，该化合物的结构式如式（I）所示，该化合物及其药学上可接受的盐可用作TRPC4/5抑制剂及制备治疗角质细胞病变相关的皮肤疾病的药物。