Synthesis method of catalyst ligand material

The present invention relates to the field of organic compound preparation, particularly to a catalyst ligand material synthesis method, which comprises: S1, carrying out a Grignard reaction by using 3, 5-di-tert-butyl bromobenzene as an initial raw material to obtain a Grignard product; s2, under t...

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Bibliographische Detailangaben
Hauptverfasser: WANG WENTAO, KOU YANJIE, LI HONGYANG, ZHANG ZHAO, FENG SHAOQUAN, LI SHUGUO, WEI YANSHAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to the field of organic compound preparation, particularly to a catalyst ligand material synthesis method, which comprises: S1, carrying out a Grignard reaction by using 3, 5-di-tert-butyl bromobenzene as an initial raw material to obtain a Grignard product; s2, under the catalytic action, the Grignard product obtained in the step S1 and 2-bromo-4-tert-butylphenol are subjected to a coupling reaction, and an intermediate II is obtained; s3, the intermediate II is subjected to a bromination reaction under the action of a brominating agent to obtain a brominated product, the intermediate product does not need to be purified and separated, and S4, the brominated product in the S3 and benzyl bromide are subjected to an etherification reaction to obtain a target product I, and the target product I is 2-benzyloxy-3-bromo-5, 3, 5-tri-tert-butylbiphenyl. The method is simple and safe in process, high in selectivity, free of separation of intermediate products, high in product quality and