Oseltamivir warning structure impurity C10-B-ZZ7 as well as preparation method and application thereof

The invention discloses an oseltamivir phosphate warning structure impurity C10-B-ZZ7, a preparation method of the oseltamivir phosphate warning structure impurity C10-B-ZZ7 and application of the oseltamivir phosphate warning structure impurity C10-B-ZZ7 as an oseltamivir impurity reference substance in oseltamivir intermediate E, raw material medicine and preparation quality research. The control limit in an oseltamivir intermediate E and a raw material medicine is not more than 7.6 ppm. The preparation method disclosed by the invention is low in cost, large-scale synthesis can be carried out, a reference substance is provided for qualitative and quantitative analysis of the oseltamivir phosphate impurity, and meanwhile, the invention further discloses a detection method of the impurity in an oseltamivir intermediate E, so that a foundation is laid for quality research of oseltamivir phosphate raw material medicines and related preparations, and the application prospect is broad. 本发明公开了磷酸奥司他韦警示结构杂质C10-B-ZZ7