Application of near-infrared probe CelTrac1000 in tracing neural stem cells

The invention belongs to the technical field of biological medicine, and provides application of a near-infrared probe CelTrac1000 in tracing neural stem cells. The research finds that the near-infrared probe CelTrac1000 can visualize the in-vivo activity of transplanted stem cells in real time thro...

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Hauptverfasser: LYU SHANGRUI, ZHU GUOCHEN, XIAO DAJIANG, ZHANG JING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological medicine, and provides application of a near-infrared probe CelTrac1000 in tracing neural stem cells. The research finds that the near-infrared probe CelTrac1000 can visualize the in-vivo activity of transplanted stem cells in real time through near-infrared imaging, non-invasive repeated imaging of the same group of animals is achieved, the fate of the transplanted cells is preliminarily revealed, and a powerful tool is provided for exploring the stem cell treatment mechanism and optimizing the cell therapy. 本发明属于生物医药技术领域,本发明提供了近红外探针CelTrac1000在示踪神经干细胞中的应用。本发明研究发现,近红外探针CelTrac1000利用近红外成像可使移植干细胞的体内活动实时可视化,实现对同一组动物非侵入性的重复成像,初步揭示了移植细胞的命运,为探究干细胞治疗机制及优化细胞疗法提供了有力的工具。