NKp46 antibody as well as preparation method and application thereof

The invention discloses an antibody targeting NKp46 as well as a preparation method and application thereof. In particular, the invention discloses a novel human monoclonal antibody targeting NKp46 (Nuclear Kinase Protein 46). The invention also discloses a method for preparing the monoclonal antibo...

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Bibliographische Detailangaben
Hauptverfasser:	YANG DAZHI, HAN YE, SONG NINGNING, MIN CHENYU, DAI CHAOHUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The invention discloses an antibody targeting NKp46 as well as a preparation method and application thereof. In particular, the invention discloses a novel human monoclonal antibody targeting NKp46 (Nuclear Kinase Protein 46). The invention also discloses a method for preparing the monoclonal antibody. The monoclonal antibody disclosed by the invention can be combined with an NKp46 antigen with high specificity, and has very high affinity and remarkable anti-tumor activity and the like. 本发明公开了一种靶向NKp46的抗体、其制备方法和用途。具体地，本发明公开了一种新的靶向NKp46的人源单克隆抗体。本发明还公开了制备所述的单克隆抗体的方法。本发明的单克隆抗体能够高特异性地结合NKp46抗原，其具有很高的亲和力并且具有显著抗肿瘤等活性。