Production method of anthranilamide derivative

The invention provides a production method of an anthranilamide derivative, which comprises the following steps: S1) respectively conveying a mixed solution A of an anthranilic acid derivative, a solvent and an organic alkali and a mixed solution B of triphosgene and the solvent into a first continu...

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Hauptverfasser: WANG DASHENG, WANG QINBO, WANG MINGLI, YAN FUPENG, JIA XUQING, CHE ZUXIAO, LIU RUIJUAN, XIANG ZIXI, SUN MEILING, SUN KENA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a production method of an anthranilamide derivative, which comprises the following steps: S1) respectively conveying a mixed solution A of an anthranilic acid derivative, a solvent and an organic alkali and a mixed solution B of triphosgene and the solvent into a first continuous reactor, and carrying out cyclization reaction at 55-90 DEG C to obtain a cyclization reaction solution; s2) treating the cyclization reaction liquid by using alkali liquor to obtain treated cyclization reaction liquid; and S3) respectively conveying the treated cyclization reaction solution and organic amine or an aqueous solution of the organic amine into a second continuous reactor, and carrying out aminolysis reaction at 55-85 DEG C to obtain an aminolysis reaction solution containing the anthranilamide derivative. According to the invention, the cyclization reaction is carried out by adopting the continuous reactor at a relatively high temperature, and the obtained cyclization reaction liquid is treated by