Method of selection of polulation or subpopulation of sample

一种应用较重的密实粒子和重力沉积从生物样本中分离出选定的所需或不需组群的分离程序。粒子具有一个或多个反应剂连结在其上，该反应剂专门针对所选定的组群并容易与它连结。粒子与样本的混合最好是使粒子反复通过样本的相当大的部分进行沉积以便与选定的组群连结。然后最好使粒子和连结在其上的选定的组群在样本内沉积，包括非选定组群的上层清液可从粒子和连结着的选定组群上分开。粒子可以加热以便杀菌并清除内毒素。 A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population then are allowed to preferentially settle in the sample and the supernatant including an enriched population is separated from the particles with the selected population bound thereto. The enriched populations in the biological sample supernatant can be further enriched by multiple removal steps.