Triple agonists of GLP-1, GCG and GIP receptors

The invention relates to a triple agonist of GLP-1, GCG and GIP receptors. The compound provided by the invention has strong agonist activity on a glucagon-like peptide-1 (GLP-1) receptor, a glucagon (GCG) receptor and a glucose-dependent insulin-enteric-accelerator (GIP) receptor; the compound can...

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Hauptverfasser:	ZHOU LINJUN, CAO XIAOLIAN, JIANG PENG, JIANG YAN, GUO LINFENG, XIAO LIN, CHENG XIAOLI, LI JING, LI WENJIA, LEI DAN, MAO JIANMING, SUN NINGYUAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a triple agonist of GLP-1, GCG and GIP receptors. The compound provided by the invention has strong agonist activity on a glucagon-like peptide-1 (GLP-1) receptor, a glucagon (GCG) receptor and a glucose-dependent insulin-enteric-accelerator (GIP) receptor; the compound can be used for treating and/or preventing metabolic disorders including diabetes mellitus, obesity, fatty liver diseases, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis, dyslipidemia, metabolic syndromes and related diseases. 本发明涉及一种GLP-1、GCG和GIP受体的三重激动剂，本发明提供的化合物对胰高血糖素样肽-1(GLP-1)受体、胰高血糖素(GCG)受体和葡萄糖依赖的肠促胰岛素(GIP)受体都具有强的激动活性；其可用于治疗和/或预防包括糖尿病、肥胖症、脂肪肝病、非酒精性脂肪性肝疾病、非酒精性脂肪性肝炎、血脂异常和代谢综合征及相关病症在内的代谢紊乱。