Deuterated azaindole bipyrazole compound, pharmaceutical composition and application

Deuterated azaindole bipyrazole compound, pharmaceutical composition and application

The invention discloses a compound as shown in a formula I, or pharmaceutically acceptable salt, isomer, metabolite, prodrug, solvate or hydrate, pharmaceutical composition and application thereof. The compound as shown in the formula I provided by the invention has good inhibitory activity on Auror...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHANG GUANGYONG, CAI JIACHANG, XU XIUXIU, KONG YAYUN
Format: Patent
Sprache:chi ; eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses a compound as shown in a formula I, or pharmaceutically acceptable salt, isomer, metabolite, prodrug, solvate or hydrate, pharmaceutical composition and application thereof. The compound as shown in the formula I provided by the invention has good inhibitory activity on Aurora kinase and has a good treatment effect on cancers. 本发明公开了式I所示化合物、或其药学上可接受的盐、异构体、代谢产物、前药、溶剂合物或水合物，药物组合物和用途。本发明提供的式I所示化合物对Aurora激酶具有很好的抑制活性，对癌症具有良好的治疗作用。