Vaccines for plague

本发明提供一种保护人或动物免受鼠疫耶尔森氏菌侵害的方法，该方法包括给机体接种疫苗，接种的疫苗包括一定形式的鼠疫耶尔森氏菌V抗原、F#-[1]抗原或这两种抗原的保护性表位，但不是完整的鼠疫耶尔森氏菌细胞。抗原优选以活疫苗形式或以重组生产的分离和/或纯化的蛋白质进行接种，编码完整或部分F#-[1]抗原以及编码完整或部分V抗原的DNA可直接用作基因疫苗。 PCT No. PCT/GB96/00571 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 13, 1996 PCT Pub. No. WO96/...

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Bibliographische Detailangaben
Hauptverfasser:	E.D. WILLIAMSON, S.E.C. LEARY, R.W. TITBALL
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	本发明提供一种保护人或动物免受鼠疫耶尔森氏菌侵害的方法，该方法包括给机体接种疫苗，接种的疫苗包括一定形式的鼠疫耶尔森氏菌V抗原、F#-[1]抗原或这两种抗原的保护性表位，但不是完整的鼠疫耶尔森氏菌细胞。抗原优选以活疫苗形式或以重组生产的分离和/或纯化的蛋白质进行接种，编码完整或部分F#-[1]抗原以及编码完整或部分V抗原的DNA可直接用作基因疫苗。 PCT No. PCT/GB96/00571 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 13, 1996 PCT Pub. No. WO96/28551 PCT Pub. Date Sep. 19, 1996A method of protecting a human or animal body from the effects of infection with Y. pestis is provided comprising administering to the body a vaccine including Yersinia pestis V antigen and Yersinia pestis F1 antigens or a protective epitopic part of each of these in a form other than whole Y. Pestis organisms. Preferably the antigens are administered in the form of a live vaccine or as recombinantly produced isolated and/or purified proteins. DNA encoding the whole or part of the F1 antigen and DNA encoding the whole or part of the V antigen may be used directly as a agnetic vaccine.