HPLC (High Performance Liquid Chromatography) detection method and application of Alagog sodium

The invention relates to the technical field of detection, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method and application of Alagog sodium. According to the HPLC detection method of the Alagog sodium, a mobile phase A is a 0.01%-0.1% triethylamine soluti...

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Hauptverfasser: TAO XIUMEI, SHAO ZHENGFEI, YAO JIA, WEN YOUYING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of detection, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method and application of Alagog sodium. According to the HPLC detection method of the Alagog sodium, a mobile phase A is a 0.01%-0.1% triethylamine solution, and the pH value of the triethylamine solution is adjusted to 5.0-6.0 with phosphoric acid; the mobile phase B is a mixed solution of acetonitrile and methanol, and the volume ratio of acetonitrile to methanol is (0.9-1.1): 1. The detection method disclosed by the invention has the advantages of very high sensitivity and separation degree, good repeatability result, simplicity in operation, stable and reliable result and low detection cost, and has important significance on quality control of the ilagog sodium raw material and safe use of the ilagog sodium tablet. 本发明涉及检测技术领域,具体公开了一种艾拉戈克钠的HPLC检测方法及应用。本发明的艾拉戈克钠的HPLC检测方法,流动相A为0.01%~0.1%三乙胺溶液,所述三乙胺溶液以磷酸调pH为5.0~6.0;所述流动相B为乙腈和甲醇的混合溶液,其中,乙腈和甲醇的体积比为(0.9~1.1):1。本发明的检测方