Application of gene modified CAR-T cell in prevention of tumor recurrence

The invention discloses an application of a myc gene in prevention of tumor recurrence by modifying CAR-T (Chimeric Antigen Receptor-T) cells. The myc gene is used for modifying the CAR-T cells, and the modified CAR-T cells can prolong the in-vivo duration of the CAR-T cells, so that tumor recurrenc...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN LYUZHE, LI SHIQI, WANG SANBIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an application of a myc gene in prevention of tumor recurrence by modifying CAR-T (Chimeric Antigen Receptor-T) cells. The myc gene is used for modifying the CAR-T cells, and the modified CAR-T cells can prolong the in-vivo duration of the CAR-T cells, so that tumor recurrence can be prevented; and a new way is provided for clinical tumor treatment, recurrence prevention and drug development. 本发明公开了myc基因通过修饰CAR-T细胞在防止肿瘤复发中的应用；利用myc基因对CAR-T细胞进行修饰，修饰后的CAR-T细胞可延续其在体内的存续时间，可防止肿瘤复发；为临床肿瘤的治疗和防复发以及药物研制提供了新的途径。