2, 4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors

2, 4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors

Compounds of general formula (I) are provided that are useful in the treatment of ATR kinase mediated diseases, such as proliferative diseases, such as cancer. Also provided are pharmaceutical compositions of the compounds of general formula (I), their use for the treatment of ATR kinase mediated di...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG HONGLEI, LIU YANAN, LI JINGTAO, ZHOU LIYING, MAO LI, LI JING, ZHONG WEITING, LIU WEINA, LIU BIN, WANG HONGJUN, XU HUIFEN, ZHAO JING, HUANG CHUANGCHUANG, ZHAO YANPING, JIANG YUANYUAN, TIAN NANA
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of general formula (I) are provided that are useful in the treatment of ATR kinase mediated diseases, such as proliferative diseases, such as cancer. Also provided are pharmaceutical compositions of the compounds of general formula (I), their use for the treatment of ATR kinase mediated diseases, and their preparation. 提供通式(I)化合物，它们可用于治疗ATR激酶介导的疾病，例如增生性疾病，例如癌症。还提供通式(I)化合物的药物组合物、其用于治疗ATR激酶介导的疾病的用途、及其制备。