Preparation method of votioxetine

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of vothioxetine, 2-(2, 4-dimethylphenylsulfanyl) aniline and dichloro ethyl amine salt react under the condition of alkali and a catalyst to obtain vothioxetine, the catalyst is potassium iodide or sodium iodide, and the alkali is potassium carbonate, sodium carbonate or cesium carbonate; the method can effectively improve the yield and purity of the product. 本发明属于医药制备技术领域，具体是涉及一种伏硫西汀的制备方法，在碱和催化剂条件下，2-(2,4-二甲基苯基硫烷基)苯胺和双氯乙基胺盐反应，得到伏硫西汀，所述催化剂为碘化钾或碘化钠，所述碱为碳酸钾、碳酸钠或碳酸铯；本发明可以有效的提高产物的收率和纯度。