Copper-catalyzed regioselective iodination formylation of terminal alkyne to generate (E)-beta-iodo-alpha, beta-unsaturated aldehydes

The invention aims to provide an efficient, simple and convenient method for preparing an (E)-beta-iodo-alpha, beta-unsaturated aldehyde skeleton by taking cheap copper as a catalyst. The reaction shows tolerance to various terminal alkynes, the corresponding product has high chemical selectivity and regioselectivity, and the reaction conditions are mild. The catalysis scheme has the advantages of wide raw materials, no noble metal or harmful byproducts and the like. Meanwhile, related transformation is successfully carried out on the products, and the practical value of the products is shown. 本发明目的在于提供一种以廉价铜为催化剂制备(E)-β-碘代-α,β-不饱和醛骨架的高效、简便的方法。反应对各种末端炔烃表现出耐受性，相应产物具有较高的化学选择性和区域选择性，且反应条件温和。该催化方案具有原料广泛、无贵金属和有害副产品等优点。同时，成功的将这些产品进行了相关转化，展现了其实用价值。