Synthetic method of isoindolo isoquinoline spironaphthalene ketone compound

The invention discloses a synthesis method of an isoindolo isoquinoline spironaphthalene ketone compound. The key point of the technical scheme is as follows: an isoquinolinone compound 1 and a 1-diazonaphthalene-2 (1H)-ketone compound 2 are taken as initial raw materials, and under the combined action of a rhodium catalyst, a silver oxidant and acid, the 2 'H, 5H-spiro [isoindole [2, 1-b] isoquinoline-7, 1'-naphthalene]-2 ', 5-diketone compound is obtained through an oxidation spiro-cyclization reaction. The method has the advantages of simple and easily-prepared initial raw materials, wide substrate range, simple operation steps and the like. 本发明公开了异吲哚并异喹啉螺萘酮类化合物的合成方法。本发明技术方案要点为：以异喹啉酮类化合物1和1-重氮萘-2(1H)-酮类化合物2为起始原料，在铑催化剂、银氧化剂和酸共同作用下，氧化螺环化反应得到2'H,5H-螺[异吲哚[2,1-b]异喹啉-7,1'-萘]-2',5-二酮类化合物。本发明具有起始原料简单易制备、底物范围广、操作步骤简单等优点。