Application of ZIP1 as epilepsy treatment target

The invention discloses application of ZIP1 as an epilepsy treatment target. The research finds that cerebral cortex epilepsy-like discharge induced by 4-AP is related to increase of ZIP1, the increase of ZIP1 can cause reduction of membrane protein expression of GluA2, and knock-down of ZIP1 can in...

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Hauptverfasser:	ZONG LINYUE, DING RAN, KANG JIAMIN, YU YONGHAO, LI YIZE, QIAO DAN, ZHANG LINLIN, LI YUANJIE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses application of ZIP1 as an epilepsy treatment target. The research finds that cerebral cortex epilepsy-like discharge induced by 4-AP is related to increase of ZIP1, the increase of ZIP1 can cause reduction of membrane protein expression of GluA2, and knock-down of ZIP1 can inhibit reduction of 4-AP induced GluA2 membrane expression. Therefore, the research proves that the ZIP1 is a key protein related to epilepsy, and the severity and severity of epilepsy can be reduced by inhibiting the ZIP1. 本发明公开了ZIP1作为癫痫治疗靶标的应用。本研究发现，4-AP诱发的大脑皮层癫痫样放电与ZIP1的增加相关，而ZIP1的增加可以引起GluA2的膜蛋白表达的降低，ZIP1的敲低可抑制4-AP诱发的GluA2膜表达降低。因此本研究证明ZIP1是癫痫相关的关键蛋白，而抑制ZIP1可以降低癫痫发作和严重程度。