Fc variants and preparation thereof

The invention relates to Fc variant proteins and preparation thereof. The Fc variants have an altered binding affinity for FcRn. The Fc variant prepared according to the invention can be used for preparing an FcRn antagonist composition or can be used for preparing a drug or molecule containing the Fc variant with a changed effector function. 本发明涉及Fc变体蛋白及其制备。所述Fc变体对FcRn具有改变的结合亲和力。根据本发明制备的Fc变体可以用于制备FcRn拮抗剂组合物或者可以用于制备具有改变的效应子功能的含有Fc变体的药物或分子。