Methods of treating osteoarthritis

The present invention provides methods of treating osteoarthritis by administering an alpha Klotho protein and an sTGF beta-R2 protein to a site (e.g., the knee joint) in a mammal exhibiting symptoms of osteoarthritis. The alpha Klotho protein and the sTGF beta-R2 protein both exist at the osteoarth...

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Bibliographische Detailangaben
Hauptverfasser:	IZPISUA BELMONTE JUAN CARLOS, REDONDO PABLO MANUEL, GUILLEN GARCIA PABLO, GIELEN-GILLEN, ISABELLE, DAVIDSON NATHAN, CHURCH GEORGE M
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides methods of treating osteoarthritis by administering an alpha Klotho protein and an sTGF beta-R2 protein to a site (e.g., the knee joint) in a mammal exhibiting symptoms of osteoarthritis. The alpha Klotho protein and the sTGF beta-R2 protein both exist at the osteoarthritis part. 本发明提供了通过向表现出骨关节炎症状的哺乳动物内的部位(例如膝关节)给予αKlotho蛋白和sTGFβ-R2蛋白来治疗骨关节炎的方法。αKlotho蛋白和sTGFβ-R2蛋白均存在于骨关节炎部位。