PILRA ANTIBODIES AND METHODS OF USE THEREOF

The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such antibodies or antigen-binding fragments thereof. In particular aspects, the antibodies or antigen-binding fragments thereof that specifically bind to human PILRA block binding of PILRA to ligands and/or reduce cell surface PILRA. In other aspects, the antibodies or antigen-binding fragments may be used to treat diseases or conditions associated with bone marrow cell dysfunction. 本公开提供了特异性结合人PILRA的抗体及其抗原结合片段以及包含此类抗体或其抗原结合片段的组合物。在特定方面，所述特异性结合人PILRA的抗体或其抗原结合片段阻断PILRA与配体的结合和/或减少细胞表面PILRA。在其他方面，所述抗体或抗原结合片段可用于治疗与骨髓细胞功能障碍相关的疾病或疾患。