Nitrogen mustard-glucan polymer, preparation method thereof, self-assembled nanoparticles, drug-loaded complex and application of drug-loaded complex

The invention discloses a nitrogen mustard-glucan polymer, a preparation method of the nitrogen mustard-glucan polymer, self-assembled nanoparticles, a drug-loaded complex and application of the drug-loaded complex, relates to a medical high-molecular polymer, and aims to reduce the toxic and side effects of chemotherapeutic drugs for treating colorectal cancer at present. The nano-particles can be formed through self-assembly, and the nano-particles have oxidative stress responsiveness. Through boric acid ester bond connection, the water solubility of nitrogen mustard molecules is further improved, the acting effect of the nitrogen mustard molecules is improved, meanwhile, amphiphilic molecules are formed, nanoparticles are formed through self-assembly in a water environment, the nanoparticles have the drug entrapment capacity and have the similar tumor high ROS environment release capacity, doxorubicin serves as an indissolvable drug, and the drug entrapment capacity and the tumor high ROS environment relea