Method for detecting 1, 2, 4-triazole in triazole medicine

The invention belongs to the technical field of chromatographic analysis, and particularly relates to a method for detecting 1, 2, 4-triazole in triazole drugs. The method comprises the following steps: under the condition of a buffer solution, carrying out derivatization reaction on a triazole drug sample and a fluorenylmethoxycarbonyl chloride acetonitrile solution, and then adding a diluent to obtain a derivatization product solution; and detecting the derivatization product solution by adopting high performance liquid chromatography to obtain a qualitative and quantitative detection result of the 1, 2, 4-triazole in the triazole medicine. The conditions are as follows: octadecyl is used as a chromatographic column of a filling agent; a formic acid aqueous solution is used as a mobile phase A, and acetonitrile is used as a mobile phase B; the method is good in specificity, high in sensitivity and accurate and reliable in result, can be used for quality control of the 1, 2, 4-triazole impurity of any interm