Preparation method of doxycycline hydrochloride granules

The invention relates to the technical field of veterinary drugs, in particular to a preparation method of doxycycline hydrochloride granules, which comprises the following steps: (1) taking sodium carboxymethyl starch, adopting purified water as a solvent, and preparing a sodium carboxymethyl starch solution with the mass concentration of 5-15% as an adhesive; (2) respectively sieving doxycycline hydrochloride raw powder, anhydrous dextrose and cationic polyacrylamide with the molecular weight of 12 million, and collecting for later use; (3) the adhesive in the step (1) and the raw materials sieved in the step (2) are sequentially put into a fluidized bed for granulation, and cationic polyacrylamide and anhydrous dextrose are added according to the mass ratio of the cationic polyacrylamide to the doxycycline hydrochloride raw powder being (1.5-3): 5 and the mass ratio of the anhydrous dextrose to the doxycycline hydrochloride raw powder being (2-4): 5; in the granulation process, the air inlet temperature is