Methods of identifying dopaminergic neurons and progenitor cells

Provided herein, inter alia, are methods of determining populations of neuronal progenitor cells derived from iPSC, thereby providing a user-friendly molecular diagnostic tool for neuronal cell types, including dopaminergic neurons. The provided methods are valuable for dopaminergic neurons derived...

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Bibliographische Detailangaben
Hauptverfasser: LORING, JOHN, F, WILLIAMS ROSS, SCHULTE, BERNHARD, M, M ¨ 1 LLER, FRANZ-JOSEF, BRATT-LEAL AGNES
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Provided herein, inter alia, are methods of determining populations of neuronal progenitor cells derived from iPSC, thereby providing a user-friendly molecular diagnostic tool for neuronal cell types, including dopaminergic neurons. The provided methods are valuable for dopaminergic neurons derived from iPSC to effectively and accurately characterize their identity and function prior to their clinical application, such as treatment of Parkinson's disease or multiple sclerosis. 本文尤其提供了测定来源于iPSC的神经元祖细胞群体的方法,从而为包括多巴胺能神经元在内的神经元细胞类型提供了用户友好的分子诊断工具。所提供的方法对来源于iPSC的多巴胺能神经元在其临床应用诸如治疗帕金森氏病或多发性硬化症之前有效和精确表征其身份和功能是有价值的。