Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of said compounds; to pharmaceutical compositions comprising said compounds; and to the use...
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| creator | LORTHIOIS EDWIGE LILIANE JEANNE LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN VAUPEL ANDREA NIETO-OBERHUBER CRISTINA M WIEKEN RALF HINRICHS JUERGEN HANS-HERMANN VARIN NICOLAS LEBLANC, CATHERINE GERSPACHER, MARKUS FRITSCH CHRISTIAN FAIRHURST ROBIN ALEC LI TENGFEI TODOROV MIKHAIL MOURA CATHERINE |
| description | The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of said compounds; to pharmaceutical compositions comprising said compounds; and to the use of said compounds in the treatment of disease. The compounds are HIF2 [alpha] inhibitors or modulators.
本发明涉及具有式(I)的化合物或其药学上可接受的盐形式，其中取代基如说明书中所定义；涉及所述化合物制备中的中间体；涉及包含所述化合物的药物组合物；并且涉及所述化合物在疾病治疗中的用途。所述化合物是HIF2α抑制剂或调节剂。 |
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本发明涉及具有式(I)的化合物或其药学上可接受的盐形式，其中取代基如说明书中所定义；涉及所述化合物制备中的中间体；涉及包含所述化合物的药物组合物；并且涉及所述化合物在疾病治疗中的用途。所述化合物是HIF2α抑制剂或调节剂。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221216&DB=EPODOC&CC=CN&NR=115485275A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221216&DB=EPODOC&CC=CN&NR=115485275A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LORTHIOIS EDWIGE LILIANE JEANNE</creatorcontrib><creatorcontrib>LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN</creatorcontrib><creatorcontrib>VAUPEL ANDREA</creatorcontrib><creatorcontrib>NIETO-OBERHUBER CRISTINA M</creatorcontrib><creatorcontrib>WIEKEN RALF</creatorcontrib><creatorcontrib>HINRICHS JUERGEN HANS-HERMANN</creatorcontrib><creatorcontrib>VARIN NICOLAS</creatorcontrib><creatorcontrib>LEBLANC, CATHERINE</creatorcontrib><creatorcontrib>GERSPACHER, MARKUS</creatorcontrib><creatorcontrib>FRITSCH CHRISTIAN</creatorcontrib><creatorcontrib>FAIRHURST ROBIN ALEC</creatorcontrib><creatorcontrib>LI TENGFEI</creatorcontrib><creatorcontrib>TODOROV MIKHAIL</creatorcontrib><creatorcontrib>MOURA CATHERINE</creatorcontrib><title>Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof</title><description>The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of said compounds; to pharmaceutical compositions comprising said compounds; and to the use of said compounds in the treatment of disease. The compounds are HIF2 [alpha] inhibitors or modulators.
本发明涉及具有式(I)的化合物或其药学上可接受的盐形式，其中取代基如说明书中所定义；涉及所述化合物制备中的中间体；涉及包含所述化合物的药物组合物；并且涉及所述化合物在疾病治疗中的用途。所述化合物是HIF2α抑制剂或调节剂。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhzzs8tyC_NSylWSMxLUUgG8YozSzLz84oVSjISSxQy8zIykzJLFDw83Yx0E3MKMhIVEpNLMssySyrBOnJTSzLygbrz0xRKi1OBelKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoaGpiYWpkbmpozExagD06jky</recordid><startdate>20221216</startdate><enddate>20221216</enddate><creator>LORTHIOIS EDWIGE LILIANE JEANNE</creator><creator>LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN</creator><creator>VAUPEL ANDREA</creator><creator>NIETO-OBERHUBER CRISTINA M</creator><creator>WIEKEN RALF</creator><creator>HINRICHS JUERGEN HANS-HERMANN</creator><creator>VARIN NICOLAS</creator><creator>LEBLANC, CATHERINE</creator><creator>GERSPACHER, MARKUS</creator><creator>FRITSCH CHRISTIAN</creator><creator>FAIRHURST ROBIN ALEC</creator><creator>LI TENGFEI</creator><creator>TODOROV MIKHAIL</creator><creator>MOURA CATHERINE</creator><scope>EVB</scope></search><sort><creationdate>20221216</creationdate><title>Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof</title><author>LORTHIOIS EDWIGE LILIANE JEANNE ; LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN ; VAUPEL ANDREA ; NIETO-OBERHUBER CRISTINA M ; WIEKEN RALF ; HINRICHS JUERGEN HANS-HERMANN ; VARIN NICOLAS ; LEBLANC, CATHERINE ; GERSPACHER, MARKUS ; FRITSCH CHRISTIAN ; FAIRHURST ROBIN ALEC ; LI TENGFEI ; TODOROV MIKHAIL ; MOURA CATHERINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115485275A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LORTHIOIS EDWIGE LILIANE JEANNE</creatorcontrib><creatorcontrib>LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN</creatorcontrib><creatorcontrib>VAUPEL ANDREA</creatorcontrib><creatorcontrib>NIETO-OBERHUBER CRISTINA M</creatorcontrib><creatorcontrib>WIEKEN RALF</creatorcontrib><creatorcontrib>HINRICHS JUERGEN HANS-HERMANN</creatorcontrib><creatorcontrib>VARIN NICOLAS</creatorcontrib><creatorcontrib>LEBLANC, CATHERINE</creatorcontrib><creatorcontrib>GERSPACHER, MARKUS</creatorcontrib><creatorcontrib>FRITSCH CHRISTIAN</creatorcontrib><creatorcontrib>FAIRHURST ROBIN ALEC</creatorcontrib><creatorcontrib>LI TENGFEI</creatorcontrib><creatorcontrib>TODOROV MIKHAIL</creatorcontrib><creatorcontrib>MOURA CATHERINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LORTHIOIS EDWIGE LILIANE JEANNE</au><au>LANGLOIS JEAN-BAPTISTE GREGOIRE ALAIN</au><au>VAUPEL ANDREA</au><au>NIETO-OBERHUBER CRISTINA M</au><au>WIEKEN RALF</au><au>HINRICHS JUERGEN HANS-HERMANN</au><au>VARIN NICOLAS</au><au>LEBLANC, CATHERINE</au><au>GERSPACHER, MARKUS</au><au>FRITSCH CHRISTIAN</au><au>FAIRHURST ROBIN ALEC</au><au>LI TENGFEI</au><au>TODOROV MIKHAIL</au><au>MOURA CATHERINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof</title><date>2022-12-16</date><risdate>2022</risdate><abstract>The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of said compounds; to pharmaceutical compositions comprising said compounds; and to the use of said compounds in the treatment of disease. The compounds are HIF2 [alpha] inhibitors or modulators.
本发明涉及具有式(I)的化合物或其药学上可接受的盐形式，其中取代基如说明书中所定义；涉及所述化合物制备中的中间体；涉及包含所述化合物的药物组合物；并且涉及所述化合物在疾病治疗中的用途。所述化合物是HIF2α抑制剂或调节剂。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof |
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