Compounds and compositions that inhibit HIF2-alpha activity and methods of use thereof

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of said compounds; to pharmaceutical compositions comprising said compounds; and to the use of said compounds in the treatment of disease. The compounds are HIF2 [alpha] inhibitors or modulators. 本发明涉及具有式(I)的化合物或其药学上可接受的盐形式，其中取代基如说明书中所定义；涉及所述化合物制备中的中间体；涉及包含所述化合物的药物组合物；并且涉及所述化合物在疾病治疗中的用途。所述化合物是HIF2α抑制剂或调节剂。