PD-L1 protein degradation agent based on hydrophobic label technology and application of PD-L1 protein degradation agent

The invention discloses a PD-L1 protein degradation agent based on a hydrophobic label technology and application of the PD-L1 protein degradation agent, and belongs to the field of medicinal chemistry. The PD-L1 protein degradation agent comprises a compound or a pharmaceutically acceptable salt of the compound, wherein the structure of the compound is shown as a formula (I) or a formula (II), wherein R1 is-OCH2; r2 is a linker; and R3 is a hydrophobic group. The micromolecule degradation agent which is designed and synthesized on the basis of the HyT technology and has a good targeted degradation effect on PD-L1 protein provides a potential treatment means for treating tumors through PD-1/PD-L1 immune checkpoints. 本发明公开了基于疏水标签技术的PD-L1蛋白降解剂及其应用，属于药物化学领域。上述PD-L1蛋白降解剂包括结构如下式(I)或式(II)所示的化合物或其药学上可接受的盐：其中，R1为-OCH2；R2为连接子；R3为疏水基团。本发明基于HyT技术设计合成的具有较好的靶向降解PD-L1蛋白的小分子降解剂，为通过PD-1/PD-L1免疫检查点来治疗肿瘤提供了潜在的治疗手段。