Absorbable bone wax and preparation method thereof

The invention provides a preparation method of absorbable bone wax, which comprises the following steps: firstly, mixing glycerol and lactide according to a ratio, reacting under the catalytic condition of stannous iso-octoate to obtain star-shaped polylactic acid, and adding isocyano ethyl methacry...

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Hauptverfasser: ZHANG QI, GAO SHIJIE, ZHU CHAO, WEI RENXIONG, WEN PINGHUA, CAI LIN, ZHANG TIE, ZHANG LIPAN, YAN FEIFEI, LEI QINGJIAN, HU LI, LI XIAOYA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a preparation method of absorbable bone wax, which comprises the following steps: firstly, mixing glycerol and lactide according to a ratio, reacting under the catalytic condition of stannous iso-octoate to obtain star-shaped polylactic acid, and adding isocyano ethyl methacrylate into the star-shaped polylactic acid for continuous reaction to obtain modified star-shaped polylactic acid; secondly, adding polyethylene glycol diacrylate into the modified star-shaped polylactic acid, and performing ultraviolet irradiation crosslinking to obtain a reticular polylactic acid-polyvinyl alcohol copolymer; thirdly, mixing the reticular polylactic acid-polyvinyl alcohol copolymer, a shaping agent and a thickening agent according to a certain proportion to obtain a uniform fluid; and finally, pouring the fluid into a mold, cooling and molding, and taking out to obtain the absorbable bone wax. The absorbable bone wax prepared by the invention has good hemostatic performance and degradation performa