Application of combination or complex of pyridystatin or derivative thereof and trans-platinum compound in preparation of medicine for treating cancer

The invention relates to the field of cancers, and discloses application of a combination or a complex of pyridystatin or a derivative thereof and a trans-platinum compound in preparation of medicines for treating cancers. After the PDS is used for pretreating the cells, the accumulation of the cell...

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Bibliographische Detailangaben
Hauptverfasser: LUO QUN, GAN TIELIANG, ZHANG YANYAN, ZHAO YAO, FANG TIANTIAN, WANG FUYI, HOU YINZHU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of cancers, and discloses application of a combination or a complex of pyridystatin or a derivative thereof and a trans-platinum compound in preparation of medicines for treating cancers. After the PDS is used for pretreating the cells, the accumulation of the cells on the trans-[PtCl2 (NH3) (thiazole)] (trans-PtTz) can be improved, and the cytotoxicity of the trans-PtTz can be obviously enhanced. Aiming at the biological activity of the PDS, the PDS and the trans-platinum compound can be combined to achieve the purpose of enhancing the cytotoxicity of the trans-platinum compound; or the PDS derivative can be connected with a trans-platinum compound to synthesize a complex, so that a high-efficiency, low-toxicity and multi-target anti-tumor effect is achieved through photodynamic therapy (PDT) and photoactive chemotherapy (PACT); the compound has unique and huge application value in research and development of antitumor drugs. 本发明涉及癌症领域,公开了吡啶抑素或其衍生物和反式铂类化合物的组合或配合物在制备治疗癌症的药物中