Method for detecting sodium pyrosulfite in dopamine hydrochloride injection
The invention provides a method for detecting sodium pyrosulfite in dopamine hydrochloride, and relates to the field of pharmaceutical analysis. According to the detection method provided by the invention, a chromatographic column taking cyano silane bonded silica gel as a filling agent is adopted,...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a method for detecting sodium pyrosulfite in dopamine hydrochloride, and relates to the field of pharmaceutical analysis. According to the detection method provided by the invention, a chromatographic column taking cyano silane bonded silica gel as a filling agent is adopted, a mobile phase A is formed by taking 0.005 mol/L lauryl sodium sulfate, acetonitrile-glacial acetic acid-0. 1 mol/L disodium ethylene diamine tetraacetate (V: V: V: V) = 700: 300: 10: 2, a mobile phase B is formed by taking acetonitrile, and the content of pyrosulfurous acid is detected through gradient elution. The method has the advantages of strong anti-interference capability, good specificity, good precision, high accuracy and strong durability, can be used for detecting the content of sodium pyrosulfite in the dopamine hydrochloride injection, realizes the quality control of the dopamine hydrochloride injection by quantifying the sodium pyrosulfite, fills the blank of the technology for detecting the sodium p |
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