Method for detecting sodium pyrosulfite in dopamine hydrochloride injection

The invention provides a method for detecting sodium pyrosulfite in dopamine hydrochloride, and relates to the field of pharmaceutical analysis. According to the detection method provided by the invention, a chromatographic column taking cyano silane bonded silica gel as a filling agent is adopted,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LIU ZHENGGUANG, TONG QINGGUO, HUANG HAOXI, CHEN HUANHAI, HUANG QIN
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention provides a method for detecting sodium pyrosulfite in dopamine hydrochloride, and relates to the field of pharmaceutical analysis. According to the detection method provided by the invention, a chromatographic column taking cyano silane bonded silica gel as a filling agent is adopted, a mobile phase A is formed by taking 0.005 mol/L lauryl sodium sulfate, acetonitrile-glacial acetic acid-0. 1 mol/L disodium ethylene diamine tetraacetate (V: V: V: V) = 700: 300: 10: 2, a mobile phase B is formed by taking acetonitrile, and the content of pyrosulfurous acid is detected through gradient elution. The method has the advantages of strong anti-interference capability, good specificity, good precision, high accuracy and strong durability, can be used for detecting the content of sodium pyrosulfite in the dopamine hydrochloride injection, realizes the quality control of the dopamine hydrochloride injection by quantifying the sodium pyrosulfite, fills the blank of the technology for detecting the sodium p