Vaccine for preventing novel coronavirus South African mutant strain virus infection

The invention relates to the field of nucleic acid vaccines, and particularly provides a vaccine for preventing novel coronavirus South African mutant strain virus infection. According to the vaccine for preventing novel coronavirus South African mutant virus infection, the active ingredient is optimized novel coronavirus South African mutant mRNA, the vaccine is composed of an optimized skeleton code and an antigen coding region, and nucleotide for transcription of the vaccine is shown as SEQ ID NO.1. Efficient body fluid and cellular immune response can be induced at the same time, and good immune protection genicity is achieved. 本发明涉及核酸疫苗领域，具体而言，提供了一种预防新型冠状病毒南非突变株病毒感染的疫苗。预防新型冠状病毒南非突变株病毒感染的疫苗，活性成分为优化新型冠状病毒南非突变株mRNA，由优化骨架代码和抗原编码区构成，转录其的核苷酸如SEQ ID NO.1所示。可同时诱导高效的体液和细胞免疫应答，具备良好的免疫保护原性。