Abuse and misuse stopping transdermal system

The present invention relates to an abuse and misuse stopping transdermal patch comprising a repellent incorporated in the backing layer of the patch. The repellent may exhibit a two-stage or persistent release kinetics with an immediate portion that releases quickly when exposed to a dissolving medium and a delayed portion that releases in a delayed manner. The delayed repellent release provides a restrain of extraction of medicament from new and used patches and is used to prevent children from accidentally misusing used patches. The abuse-stopping and misuse-stopping patch system can be used for transdermal delivery of therapeutically active agents, particularly those highly susceptible to abuse, such as opiates and opioid analgesics and stimulants. 本发明涉及一种滥用制止和误用制止透皮贴剂，其包含在贴剂的背衬层中掺入的忌避剂。所述忌避剂可呈现两阶段或持久释放动力学，具有当暴露于溶解介质时快速释放的即刻部分和以延迟方式释放的延迟部分。所述延迟的忌避剂释放提供对从新的和用过的贴剂提取药物的制止，并且用于防止儿童偶然误用用过的贴剂。所述滥用制止和误用制止贴剂系统可用于透皮递送治疗活性剂，特别是高度易于滥用的那些药物，例如阿片剂和阿片样物质止痛剂和兴奋剂。