Modulators of MAS-related G protein receptor X4 and related products and methods

Provided are methods generally for modulating MRGPR X4, or more particularly for treating MRGPR X4 dependent conditions, by contacting MRGPR X4 with an effective amount of a compound having a structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, respectively, or administering to a subject in need thereof an effective amount of a compound having the structure of Formula (I) or a pharmaceutically acceptable isomer, raceme, hydrate, solvate, isotope or salt thereof, wherein m, n, p, t, A, B, Z, R1, R2 and R3 are as defined herein. Also provided are pharmaceutical compositions comprising such compounds, as well as the compounds themselves. The Mas related G protein (MRGPR) X4 modulators are in particular isoindolinones and isoquinolinones that are substituted on the carbocycle. The compounds are useful in the treatment of itch-related conditions, pain-related conditions, or autoimmune disorders. 提供了一般地用于调节MRGPR X4或更具体地用于治疗MRGPR X4依赖性状况的方法，该方法分别通过使