Anti-GPRC5D antibody as well as preparation method and application thereof

The invention discloses an anti-GPRC5D antibody and a preparation method and application thereof, the antibody comprises a heavy chain variable region and/or a light chain variable region, the heavy chain variable region comprises amino acid sequences as shown in SEQ ID NO: 29 (HCDR1), SEQ ID NO: 30...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LI XIULAN, CHU MIN, LI YANAN, WANG PING, DONG GUOLIANG, LUO XUEQIN, WEI HAITAO, SHANG YUSHUAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention discloses an anti-GPRC5D antibody and a preparation method and application thereof, the antibody comprises a heavy chain variable region and/or a light chain variable region, the heavy chain variable region comprises amino acid sequences as shown in SEQ ID NO: 29 (HCDR1), SEQ ID NO: 30 (HCDR2) and SEQ ID NO: 31 (HCDR3), and the light chain variable region comprises amino acid sequences as shown in SEQ ID NO: 47 (LCDR1), YAS (LCDR2) and SEQ ID NO: 48 (LCDR3). The anti-GPRC5D antibody has relatively strong binding activity, reaction specificity, species cross reactivity and endocytosis activity, and is suitable for treatment and product development of related diseases such as subsequent cancers. 本发明公开了抗GPRC5D抗体、其制备方法与用途，所述抗体包含重链可变区和/或轻链可变区，所述重链可变区包含SEQ ID NO:29(HCDR1)、SEQ ID NO:30(HCDR2)和SEQ IDNO:31(HCDR3)所示的氨基酸序列，所述轻链可变区包含SEQ ID NO:47(LCDR1)、YAS(LCDR2)和SEQ ID NO:48(LCDR3)所示的氨基酸序列。所述抗GPRC5D抗体具有较强的结合活性、反应特异性、物种交叉反应性和内吞活性，适应于后续癌症等相关疾病的治疗和产品开发。