Preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone

The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone, which comprises the following steps: reacting alpha-hydroxyl p-chlorobenzyl phosphonate with 2, 3-dihydrofuran in the presence of a catalyst and a solvent to obtain diethyl ((4-chlorphenyl) ((tetrahydrofuran-2...

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Bibliographische Detailangaben
Hauptverfasser: TANG ZIYING, JIANG FUGUO, BAO RUSHENG, HUO XING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone, which comprises the following steps: reacting alpha-hydroxyl p-chlorobenzyl phosphonate with 2, 3-dihydrofuran in the presence of a catalyst and a solvent to obtain diethyl ((4-chlorphenyl) ((tetrahydrofuran-2-yl) oxygen) methyl) phosphonate, and reacting the diethyl ((4-chlorphenyl) ((tetrahydrofuran-2-yl) oxygen) methyl) phosphonate with cyclopropyl methyl ketone to obtain a compound 3; and carrying out hydrolysis reaction on the compound 3 under an acidic condition. The 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone is prepared by taking alpha-hydroxy p-chlorobenzyl phosphonate as a raw material and 2, 3-dihydrofuran as a protecting group and combining with the specific catalyst, so that the reaction selectivity is improved, the reaction yield and the product purity are remarkably improved, the operation is safer and more environmentally friendly, and the method is suitable for industrial production. The purity of the pre