ANTIGEN BINDING MOLECULES AGAINST ALPPL2 AND/OR ALPP AND USES THEREOF

The present invention relates to antigen binding molecules that specifically bind to ALPPL2 and/or ALPP rather than ALPL or ALPI. The invention also relates to pharmaceutical compositions, immunoconjugates and chimeric antigen receptors comprising said antigen binding molecules. The invention also r...

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Bibliographische Detailangaben
Hauptverfasser:	FANG XINYI, LI XUETING, SUN WEIMIN, HUANG JIANDUAN, YE TAILIANG, TAN PATRICK, WANG HUAJING, WANG CHENG-I, HUANG QINGWEN, WAN JIAHUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to antigen binding molecules that specifically bind to ALPPL2 and/or ALPP rather than ALPL or ALPI. The invention also relates to pharmaceutical compositions, immunoconjugates and chimeric antigen receptors comprising said antigen binding molecules. The invention also relates to methods for reducing the expression or activity of ALPPL2 in cancer cells, and methods of treating cancer in a subject. 本发明涉及特异性结合ALPPL2和/或ALPP而非ALPL或ALPI的抗原结合分子。本发明还涉及包含所述抗原结合分子的药物组合物、免疫缀合物和嵌合抗原受体。本发明还涉及用于降低癌细胞中ALPPL2的表达或活性的方法，以及治疗受试者中癌症的方法。