Short and efficient process for preparation of (1r, 3r)-2, 2-dimethyl-3-(Z)-prop-1-en-1-yl) cyclopropanecarboxylic acids and esters

The invention relates to a method for preparing (1R, 3R)-2, 2-dimethyl-3-(Z)-propyl-1-ene-1-yl) cyclopropanecarboxylic acid [I] and salt or ester thereof from (1R, 3S)-3-(2, 2-dihalovinyl)-2, 2-dimethyl-cyclopropanecarboxylic acid as shown in a structural formula II which is easy to obtain, and salt...

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Hauptverfasser: DESAI SHIKHA NITIN, PAREKH SAMEER J, BATT, FREDRICK, A, CHAWLA HARDIK S, SOLANKI ANIL K
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a method for preparing (1R, 3R)-2, 2-dimethyl-3-(Z)-propyl-1-ene-1-yl) cyclopropanecarboxylic acid [I] and salt or ester thereof from (1R, 3S)-3-(2, 2-dihalovinyl)-2, 2-dimethyl-cyclopropanecarboxylic acid as shown in a structural formula II which is easy to obtain, and salt and ester derived from a compound as shown in the formula II according to the following reaction formulas, in particular to a method for preparing (1R, 3R)-2, 2-dimethyl-3-(Z)-propyl-1-ene-1-yl) cyclopropanecarboxylic acid [I] and salt or ester thereof. 本发明涉及一种按照如下反应式,由易得的结构式II所示的(1R,3S)-3-(2,2-二卤乙烯基)-2,2-二甲基-环丙烷羧酸,及由式II所示的化合物衍生的盐和酯,制备(1R,3R)-2,2-二甲基-3-(Z)-丙-1-烯-1-基)环丙烷羧酸[I]及其盐或酯的方法。