Schiff base trehalase inhibitor as well as preparation method and application thereof

The invention belongs to the field of pesticide preparation, and relates to a Schiff base trehalase inhibitor as well as a preparation method and application thereof. The structural formula of the derivative is shown in the specification, wherein R is one or two of H,-OH,-F,-Cl,-Br,-CH3,-O-CH3,-NO2...

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Bibliographische Detailangaben
Hauptverfasser: WU LULU, YANG RAORAO, SHI LIJUN, PAN ZHENLIANG, YANG GUOYU, CHO SANG-HOON, WANG CAIXIA, XU CUILIAN, FAN LIANGXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of pesticide preparation, and relates to a Schiff base trehalase inhibitor as well as a preparation method and application thereof. The structural formula of the derivative is shown in the specification, wherein R is one or two of H,-OH,-F,-Cl,-Br,-CH3,-O-CH3,-NO2 or-C-(CH3) 3. According to the prepared Schiff base trehalase inhibitor, a three-dimensional crystal structure of trehalase serves as a target, a glucosamine derivative with good interaction force is designed under the assistance of a computer, then synthesis and structural characterization are conducted, the fungal activity and the bacterial activity of the synthesized compound are tested, and the Schiff base trehalase inhibitor is obtained. And screening the Schiff base trehalase inhibitor with good activity. The antibacterial mechanism of the Schiff base trehalase inhibitor is that energy supply of fungi and bacteria is cut off by inhibiting trehalase to cause death of harmful organisms, and the Schiff base treh