CHIMERIC ANTIGEN RECEPTOR T CELL COMPOSITIONS AGAINST BCMA AND METHODS AND USES THEREOF

In some aspects, provided are cellular compositions for treating subjects suffering from diseases and conditions, such as multiple myeloma (MM), and related methods, compositions, uses, and articles of manufacture. In some embodiments, the disease or condition is a recurrent or refractory multiple myeloma (r/r MM). The cells generally express recombinant receptors, such as chimeric antigen receptors (CARs) targeting antigens on myeloma cells, such as BCMA. 在一些方面，提供了用于治疗患有诸如多发性骨髓瘤(MM)等疾病和病症的受试者的细胞组合物，以及相关方法、组合物、用途和制品。在一些实施方案中，所述疾病或病症是复发性或难治性多发性骨髓瘤(r/r MM)。所述细胞通常表达重组受体，诸如靶向在骨髓瘤细胞上的抗原诸如BCMA的嵌合抗原受体(CAR)。