Mesenchymal stem cell obtained through treatment of at least two cell factors of IL4, IL21 and IL27, exosome of mesenchymal stem cell and application of exosome

The invention discloses a mesenchymal stem cell treated by at least two cell factors of IL4, IL21 and IL27, an exosome of the mesenchymal stem cell and application of the mesenchymal stem cell, and relates to the technical field of biomedicine, the mesenchymal stem cell and the exosome of the mesenchymal stem cell are obtained after the mesenchymal stem cell is pretreated by a cell factor composition, the method for preparing the mesenchymal stem cells comprises the following steps: performing staged treatment stimulation on the mesenchymal stem cells by using a complete culture medium containing a cytokine composition to obtain energized mesenchymal stem cells; the exosome is prepared by the following steps: performing staged treatment stimulation on mesenchymal stem cells by using a complete culture medium containing a cytokine composition, and then performing starvation treatment on the mesenchymal stem cells by using a basic culture medium; the mesenchymal stem cells and the exosomes thereof, which are ob