Preparation and application of oligopeptide modified bisindoleethyl-beta-carboline-3-carboxylic acid

The invention discloses 7 oligopeptide modified N-(1-(3, 4-difluorophenyl)-1-(1-(3, 4-difluorophenyl)- The invention relates to a compound shown in the formula (I), in particular to 3, 3 '-diindole) ethyl-beta-carboline-3-carboxylic acid (in the formula, Peptide represents Arg-Gly-Asp-Ser, Arg-Gly-Asp-Phe, Arg-Gly-Asp-Val, Tyr-Ile-Gly-Ser-Arg, Tyr-Ile-Gly-Ser-Lys, Leu-Asp-Val or Lys-Glu), discloses a synthesis method of the compound and activity of the compound in inhibiting tumor growth, and further discloses activity of the compound in inhibiting tumor metastasis to the lung and application of the compound in preparation of anti-tumor drugs. 本发明公开了具有下式结构的7种寡肽修饰的N-(1-(3,3'-二吲哚)乙基-β-咔啉-3-羧酸(式中Peptide代表Arg-Gly-Asp-Ser,Arg-Gly-Asp-Phe,Arg-Gly-Asp-Val,Tyr-Ile-Gly-Ser-Arg,Tyr-Ile-Gly-Ser-Lys,Leu-Asp-Val或Lys-Glu)，公开了它们的合成方法，抑制肿瘤生长的活性，还进一步公开了它们抑制肿瘤向肺转移的活性及其在制备抗肿瘤药物中的应用。